2015-02-03|The Royal's Mental Health Research Series: GABA, Depression and Aging
Dr. Etienne Sibille
Congratulations for interesting lecture "GABA, Depression and Aging" at Royal Ottawa Mental Health Centre on 2015-02-03.
I am thinking that many of the experimental results of your research, which is based on gene expression or cellular phenotype of genetic and environmental models, could be re-organised to be interpreted in the paradigm of epigenetics? If it is possible, then there could be new discovery of epigenetic mechanism for the results that had not been explained in the past.
There is evidence in humans that prenatal exposure to maternal stress can increase the risk of subsequently developing schizophrenia. The epigenetic changes have been found to be reversible in adulthood following methionine supplementation or treatment with histone deacetylase (HDAC) inhibitors.
Eventually, epigenetic therapies could become possible in treating neurological disorders including depression, schizophrenia and bipolar disorder.
